Past Projects
Management of Resistance to Tyrosine Kinase Inhibitors with Advanced Nanosystems
FP7-PEOPLE-IAPP: NANORESISTANCE 286125
Duration: November 2011 - October 2015
Funding: € 1,400.000
Principal Investigator: A. Odysseos.
NANORESISTANCE introduces for the first time (i) receptor -independent targeting of Epidermal Growth Factor Receptor-kinase activity, (ii) nuclear delivery of anti-Epidermal Growth Factor Receptor therapy with novel grafting techniques and (iii) the deciphering of resistance and lack of responsiveness to anti-EGF...
Mechanistic Approaches in Cellular and Biological Barriers- Sub-project: The Blood-Brain Tumour Barrier FP7-PEOPLE-ITN: PATHCHOOSER
Duration: October 2013 - September 2017
Funding: € 3,178.803
Lead of Training: A. Odysseos
Nanomedicine offers capability to significantly change the course of treatment for lifethreatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecule...
Multipotent Theranostic Metal-Based Scaffolds for Molecular Targeting of Colorectal Cancer (Cyprus Research Promotion Foundation; 2012-2015)
Duration: June. 2012 - May. 2014
Funding: € 178.803
Project Coordinator: C. Pitris ; Partner: A. Odysseos
This project brings together expertise in medical optics and optoelectronics, magnetics, coordinate Lanthanide chemistry, bio-organic synthesis and molecular oncology, aiming at introducing a break-through solution for the overall management of colorectal cancer and potentially other malignancies expressing the epidermal growth factor family of receptors (EGFR). Th...
Nanofiber Electrospinning and Rapid Prototyping for Intestinal Tissue Engineering (Cyprus Research Promotion Foundation; 2009-2011)
Funding: €137.688
Partner and Deputy Coordinator, A. Odysseos
Adaptation of Nanofiber Electrospinning for Rapid Prototyping: A mesoscale-resolution electrospinning RP system based on a 3-axis CNC machine was set up and configured. A collector for layered deposition based on spraying of graphite microparticles in sacrificial intermediate layers was tested, as well as a polystyrene foil mask on the target to patern electrospun areas The innovative idea of st...
Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells. COST CM1106 (2012-2016)
This COST Action aims to unite researchers with expertise in rational drug design and the medicinal chemistry of synthetic and natural compounds with biomedical investigators dedicated to the understanding the mechanisms governing drug resistance in cancer stem cells. Cancer stem cells (CSC) are a subpopulation of cells within tumors that exhibit enhanced tumor-initiating attributes and are a major contributing factor to current cancer therapy failure. The CSC phenotypic state com...