Imagine a revolution in personalized healthcare and disease prevention systems in Europe, based on human avatars of healthy individuals and patients for the prevention, interception and cure of disease. Nothing less is the aim of the First International Symposium on Digital Twins in Healthcare, taking place in Ayia Napa, Cyprus on May 16-17, 2024 (DigitalTwin4Health2024). This unprecedented event aspires to become the stage for multidisciplinary initiatives in Europe aiming for a paradigm shift in healthcare and for a future sustainable healthcare system.